Prevention of scarring in experimental pyelonephritis in the rat by early antibiotic therapy.

@article{Slotki1982PreventionOS,
  title={Prevention of scarring in experimental pyelonephritis in the rat by early antibiotic therapy.},
  author={Itzchak N Slotki and A. William Asscher},
  journal={Nephron},
  year={1982},
  volume={30 3},
  pages={262-8}
}
Experimental pyelonephritis was produced by either retrograde or direct infection of rat kidneys by Escherichia coli 078. Combined antibiotic therapy with amoxycillin and gentamicin, commenced within 23 h of direct infection, prevented acute suppuration and subsequent scarring. The same antibiotics combination commenced 24 h after both retrograde and direct infection did not significantly reduce acute suppuration but did reduce scarring. Treatment begun later than 24 h after infection had no… CONTINUE READING