Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug.

@article{Fox1986PreventionOR,
  title={Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug.},
  author={Martijn Fox and M J Otto and Mark A. Mckinlay},
  journal={Antimicrobial agents and chemotherapy},
  year={1986},
  volume={30 1},
  pages={
          110-6
        }
}
WIN 51711, a potent new antipicornavirus drug, has been shown to inhibit an early event in the replication cycle of human poliovirus type 2 and human rhinovirus type 2. WIN 51711 was not virucidal and had no measurable effect on the adsorption of [3H]uridine-labeled virions to cells. When virion penetration of the plasma membrane was determined through loss of sensitivity to neutralizing antisera, WIN 51711 had no effect on poliovirus penetration, but inhibited rhinovirus penetration by 40%. In… CONTINUE READING

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