Prevention of renal ischemia-reperfusion injury by short hairpin RNA of endothelin A receptor in a rat model.

@article{Jia2012PreventionOR,
  title={Prevention of renal ischemia-reperfusion injury by short hairpin RNA of endothelin A receptor in a rat model.},
  author={Yichen Jia and Zitong Zhao and Ming Xu and Tian Zhao and Yongyin Qiu and Yitreen Ooi and Bin Yang and Ruiming Rong and Tongyu Zhu},
  journal={Experimental biology and medicine},
  year={2012},
  volume={237 8},
  pages={894-902}
}
Endothelin A receptor (ETaR) is a key molecule involved in a variety of biological events such as vessel contraction and inflammatory response in ischemia-reperfusion (I/R) injury. RNA interference using short hairpin RNA (shRNA) is a powerful tool to silence gene expression. Here, the effect of ETaR shRNA on I/R injury in rats was studied. A more effective… CONTINUE READING