Prevention of renal fibrosis by spironolactone in mice with complete unilateral ureteral obstruction.

@article{Trachtman2004PreventionOR,
  title={Prevention of renal fibrosis by spironolactone in mice with complete unilateral ureteral obstruction.},
  author={Howard A. Trachtman and Adam C. Weiser and Elsa Valderrama and Maria Jos{\'e} Lenharo Morgado and L. Scott Palmer},
  journal={The Journal of urology},
  year={2004},
  volume={172 4 Pt 2},
  pages={
          1590-4
        }
}
PURPOSE Recent data suggest that aldosterone directly mediates cardiac fibrosis and hypertensive nephrosclerosis. We conducted experiments to determine whether administration of spironolactone, a mineralocorticoid receptor antagonist, reduced renal fibrosis in an experimental model of obstructive uropathy. MATERIALS AND METHODS Complete unilateral ureteral obstruction (UUO) was created surgically in 8 to 10-week-old male C57BL/6 mice by placing sutures around the right ureter. Spironolactone… CONTINUE READING
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