Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition.

@article{Wilson2017PreventionOR,
  title={Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition.},
  author={Patricia G. Wilson and Joel C. Thompson and Meghan H. Yoder and Richard J. Charnigo and Lisa R. Tannock},
  journal={Journal of lipid research},
  year={2017},
  volume={58 12},
  pages={
          2264-2274
        }
}
Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of renal lipid (apoB) accumulation attenuates DN. Biglycan-deficient and biglycan wild-type Ldlr-/- mice were made diabetic via streptozotocin and fed a high cholesterol diet. As biglycan deficiency is… CONTINUE READING
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