Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.

@article{Faustman1984PreventionOR,
  title={Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.},
  author={Denise L Faustman and Ralph Marvin Steinman and Howard M. Gebel and Věra Hauptfeld and Joseph M. Davie and Paul E. Lacy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 12},
  pages={
          3864-8
        }
}
Previously we have demonstrated that islets of Langerhans treated with donor-specific anti-Ia serum and complement survive when transplanted across the major histocompatibility complex of the mouse. In this study, using immunofluorescence, we demonstrate two morphologically distinct populations of Ia-positive cells scattered within the Ia-negative islet tissue. A large irregularly shaped Ia-positive subset of cells were identified as dendritic cells by using the 33D1 antibody specific for a… CONTINUE READING

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