Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial.

@article{Attal1993PreventionOR,
  title={Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial.},
  author={Michel Attal and Françoise Huguet and Herv{\'e} Rubi{\'e} and J. P. Charlet and Daniel Schlaifer and Anne Huynh and Guy Laurent and Jacques Pris},
  journal={Blood},
  year={1993},
  volume={82 3},
  pages={732-6}
}
Elevated levels of tumor necrosis factor alpha (TNF-alpha) have been reported to correlate with the development of transplant-related complications after bone marrow transplantation (BMT). In a recent phase I-II trial, oral administration of pentoxifylline (PTX), a xanthine derivative capable of downregulating TNF-alpha production in vitro, was reported to reduce morbidity and mortality in patients undergoing BMT. We conducted a prospective randomized trial of PTX therapy among 140 patients… CONTINUE READING
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