Prevention of recurrent exertional rhabdomyolysis by dantrolene sodium.


A patient with recurrent attacks of exertional rhabdomyolysis and easy fatiguability was treated with dantrolene sodium. She experienced a complete prevention of myoglobinuric attacks and gained a better exercise tolerance. Biochemical findings in this patient suggest a loosely coupled oxidative phosphorylation in mitochondria. The question is raised as to… (More)