Prevention of radiolysis of monoclonal antibody during labeling.

  title={Prevention of radiolysis of monoclonal antibody during labeling.},
  author={Madhura Chakrabarti and Nhat X. T. Le and Chang H Paik and William G De Graff and Jorge A. Carrasquillo},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={37 8},
UNLABELLED Monoclonal antibody may undergo loss of immunoreactivity due to radiation damage when labeled with large amounts of 131I or 90Y for therapy. Our aim was to develop a method to protect an antibody during the labeling procedure. METHODS As a model we used T101, a murine monoclonal antibody directed against CD5 antigen. Iodine-125-T101 (100 micrograms, 1 ml) was mixed with 90Y-DTPA (0.64 MBq to 165.9 MBq) for 24 hr in order to deliver doses of 5 Gy to 1280 Gy to the solution. In… CONTINUE READING
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