Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.

@article{Sibai1993PreventionOP,
  title={Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.},
  author={Baha M. Sibai and Steve N. Caritis and Elizabeth Thom and Mark A Klebanoff and Donald McNellis and Luigi Rocco and Richard H. Paul and Roberto L Romero and Frank Witter and Mark Rosen},
  journal={The New England journal of medicine},
  year={1993},
  volume={329 17},
  pages={1213-8}
}
BACKGROUND Although low-dose aspirin has been reported to reduce the incidence of preeclampsia among women at high risk for this complication, its efficacy and safety in healthy, nulliparous pregnant women are not known. METHODS We studied 3135 normotensive nulliparous women who were 13 to 26 weeks pregnant to determine whether treatment with aspirin reduced the incidence of preeclampsia. Of this group, 1570 women received 60 mg of aspirin per day and 1565 received placebo for the remainder… CONTINUE READING
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