Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior.

@article{Oh2005PreventionOP,
  title={Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior.},
  author={Se Heang Oh and Jin Kyeong Kim and Kyu Sang Song and Seung Noh and Sung Ho Ghil and Soon Hong Yuk and Jin Ho Lee},
  journal={Journal of biomedical materials research. Part A},
  year={2005},
  volume={72 3},
  pages={
          306-16
        }
}
Sol-gel transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The sol-gel transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body… CONTINUE READING
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