Prevention of postsurgical bleeding in oral surgery using tranexamic acid without dose modification of oral anticoagulants.

@article{Ramstrm1993PreventionOP,
  title={Prevention of postsurgical bleeding in oral surgery using tranexamic acid without dose modification of oral anticoagulants.},
  author={G{\"o}ran Ramstr{\"o}m and Steen Sindet-Pedersen and G. Hall and Margareta Blomb{\"a}ck and U Alander},
  journal={Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons},
  year={1993},
  volume={51 11},
  pages={
          1211-6
        }
}
The hemostatic effect of tranexamic acid solution (4.8%) used as a mouthwash was compared with a placebo solution in 93 patients on continuous, unchanged, oral anticoagulant treatment undergoing oral surgery. The investigation was a randomized, double-blind, placebo-controlled, multicenter study. Before suturing, the surgically treated region was irrigated with 10 mL of tranexamic acid (46 patients) or placebo (47 patients) solution. The patients then performed mouthwash with 10 mL of the… CONTINUE READING
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