Prevention of phosphate induced progression of experimental uremia by 3-phosphocitric acid.

@article{Walker1982PreventionOP,
  title={Prevention of phosphate induced progression of experimental uremia by 3-phosphocitric acid.},
  author={William G. Walker and Luis F. Gimenez and William P. Tew and Judith A. Hermann},
  journal={Advances in experimental medicine and biology},
  year={1982},
  volume={151},
  pages={
          157-66
        }
}
Excess dietary phosphate produces progressive increase in calcium content of the kidney and also leads to progressive deterioration of renal function1–3. The important variables responsible for determination of both the rate of deposition of calcium and loss of renal function are the quantity of dietary phosphate, the amount of functioning renal tissue and the level of parathyroid activity3,4. Given sufficient reduction in the size of the functioning renal mass, progressive deposition of… Expand
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Recent observations by Brenner and his colleagues in experimental animals suggest that renal haemodynamic factors play a preponderant role in the initiation and progression of chronic renal failure; following an initial reduction in functional renal mass, compensatory haemodynamics changes take place in the remnant glomeruli. Expand

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