Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats.

@article{Kikkawa1984PreventionOP,
  title={Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats.},
  author={Ryuichi Kikkawa and I. Hatanaka and Hitoshi Yasuda and Nobuaki Kobayashi and Yukio Shigeta},
  journal={Metabolism: clinical and experimental},
  year={1984},
  volume={33 3},
  pages={212-4}
}
A potent inhibitor of aldose reductase, (E)-3-carboxy-methyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanin e (ONO-2235), was orally administered at a dose of 20 mg X kg-1 X d-1 for 2 weeks to streptozotocin-diabetic rats from the beginning of the diabetic state, ie, 24 hours after streptozotocin injection. The impairment of motor nerve conduction velocity (MNCV) of the tail nerve found in nontreated diabetic rats was apparently prevented by the treatment with the aldose reductase inhibitor (24… CONTINUE READING

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