Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.

Abstract

BACKGROUND Peripheral neuropathy is a major dose-limiting toxicity of chemotherapy, especially after multiple courses of paclitaxel. The development of paclitaxel-induced neuropathy is associated with the activation of microglia followed by the activation and proliferation of astrocytes, and the expression and release of proinflammatory cytokines in the… (More)
DOI: 10.1213/ANE.0b013e31824b0191

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Cite this paper

@article{Naguib2012PreventionOP, title={Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.}, author={Mohamed Naguib and Jijun Xu and P Orlando D{\'i}az and David L. Brown and David Cogdell and Bihua Bie and Jianhua Hu and Suzanne Craig and Walter N. Hittelman}, journal={Anesthesia and analgesia}, year={2012}, volume={114 5}, pages={1104-20} }