Prevention of osteoporosis: treatment of estradiol deficiency.


Estradiol (E2) plays a major role in maintaining women's skeletal integrity. Loss of bone mass is a regular occurrence with E2 deficiency, regardless of etiology. Estrogen-dependent bone loss follows a predictable pattern. Initially, it is quite rapid, preferentially affecting trabecular bone, which may decrease by 5-8% annually, whereas compact or cortical… (More)