Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.

@article{Ma2004PreventionOO,
  title={Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.},
  author={Li-jun Ma and Su-Li Mao and Kevin L Taylor and Talerngsak Kanjanabuch and You-fei Guan and Yahua Zhang and Nancy J. Brown and Larry L Swift and Owen P. McGuinness and David H. Wasserman and Douglas E. Vaughan and Agnes B. Fogo},
  journal={Diabetes},
  year={2004},
  volume={53 2},
  pages={336-46}
}
Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only thrombosis and fibrosis but also to obesity and insulin resistance. Increased PAI-1 levels have been presumed to be consequent to obesity. We investigated the interrelationships of PAI-1, obesity, and insulin resistance in a high-fat/high-carbohydrate (HF) diet-induced obesity model in wild-type (WT) and PAI-1-deficient mice (PAI-1(-/-)). Obesity and insulin resistance developing in WT mice on an HF diet were… CONTINUE READING

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