Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical.

  title={Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical.},
  author={Donald Babbitt and Mervyn B. Forman and Richard Hayden Jones and Ashok K. Bajaj and Richard L Hoover},
  journal={The American journal of pathology},
  volume={136 2},
Myocardial salvage after reperfusion may be limited by neutrophil-mediated microvascular damage. The effect of the perfluorochemical, Fluosol-DA, and its various components on neutrophil adherence, cytotoxicity, and proteolytic enzyme release was examined on sheep large and small vessel endothelial cells in vitro. Cells were studied under normoxic (N) and anoxic conditions (A). Various concentrations of Fluosol (10%, 25%, and 50%) significantly reduced neutrophil adherence under both… CONTINUE READING

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