Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.

@article{Behrens1999PreventionON,
  title={Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.},
  author={M Margarita Behrens and Uta Strasser and Jae Young Koh and Byoung Joo Gwag and Dennis W. Choi},
  journal={Neuroscience},
  year={1999},
  volume={94 3},
  pages={
          917-27
        }
}
Consistent with previous studies on cell lines and non-neuronal cells, specific inhibitors of protein kinase C induced mouse primary cultured neocortical neurons to undergo apoptosis. To examine the complementary hypothesis that activating protein kinase C would attenuate neuronal apoptosis, the cultures were exposed for 1 h to phorbol-12-myristate-13-acetate, which activated protein kinase C as evidenced by downstream enhancement of the mitogen-activated protein kinase pathway. Exposure to… CONTINUE READING
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