Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells.

@article{Bost2012PreventionOM,
  title={Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells.},
  author={Fr{\'e}d{\'e}ric Bost and Issam Ben-Sahra and Jean-François Tanti},
  journal={Cancer prevention research},
  year={2012},
  volume={5 4},
  pages={503-6}
}
Several experimental and epidemiologic studies have shown that the antidiabetes drug metformin has antitumor properties. The report by Algire and colleagues in this issue of the journal (beginning on page 536) shows for the first time that metformin reduces mutagenesis induced by reactive oxygen species. This report offers new perspectives on metformin in cancer prevention and provides a new mechanism for the reduction of cancer risk in diabetic patients treated with this drug. 

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