Corpus ID: 27597597

Prevention of methotrexate-induced gastrointestinal toxicity by glucose.

  title={Prevention of methotrexate-induced gastrointestinal toxicity by glucose.},
  author={Mostafa Z. Badr and T. S. Chen},
  journal={Drug-nutrient interactions},
  volume={5 1},
The effect of administration of glucose on methotrexate-induced body weight loss and gastrointestinal toxicity in mice was investigated. Using the everted sac technique, control rates (mumol/g/hr) of transport of D-glucose and L-tyrosine were 35.0 and 10.0, respectively. In animals pretreated with methotrexate (25 mg/kg/day i.p. for 4 days), these rates decreased to 10.9 and 6.3 mumol/g/hr, respectively. However, when intestinal sacs from untreated mice were exposed to MTX (10(-3) M), the drug… Expand
A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat
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