Prevention of methamphetamine-induced microglial cell death by TNF-α and IL-6 through activation of the JAK-STAT pathway

@inproceedings{CoelhoSantos2011PreventionOM,
  title={Prevention of methamphetamine-induced microglial cell death by TNF-α and IL-6 through activation of the JAK-STAT pathway},
  author={Vanessa Coelho-Santos and Joana Gonçalves and Carlos Fontes-Ribeiro and Ana Paula Silva},
  booktitle={Journal of Neuroinflammation},
  year={2011}
}
It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial cells seem to be activated in response to METH, but its effects on microglial cells are not fully understood. Moreover, it has been shown that cytokines, which are normally released by activated microglia, may have a dual role in response to brain injury. This led us to study the toxic… CONTINUE READING