Prevention of mast cell degranulation by disodium cromoglycate attenuates the development of hypoxic pulmonary hypertension in rats exposed to chronic hypoxia.

@article{Banasov2008PreventionOM,
  title={Prevention of mast cell degranulation by disodium cromoglycate attenuates the development of hypoxic pulmonary hypertension in rats exposed to chronic hypoxia.},
  author={Alena Banasov{\'a} and Hana Maxov{\'a} and V{\'a}clav Hampl and Martin V{\'i}zek and Viera Pov{\'y}{\vs}ilov{\'a} and Jana Novotn{\'a} and Olga Vajnerov{\'a} and Olga Hnilickov{\'a} and Jan Herget},
  journal={Respiration; international review of thoracic diseases},
  year={2008},
  volume={76 1},
  pages={102-7}
}
BACKGROUND Chronic hypoxia induces lung vascular remodeling, which results in pulmonary hypertension. Vascular remodeling is associated with collagenolysis and activation of matrix metalloproteinases (MMPs). One of the possible sources of MMPs in hypoxic lung are mast cells. OBJECTIVE The role of lung mast cell collagenolytic activity in hypoxic pulmonary hypertension was tested by the inhibitor of mast cell degranulation disodium cromoglycate (DSCG). METHODS Rats were treated with DSCG in… CONTINUE READING
21 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease

  • SF van Eeden, DD Sin
  • Respiration
  • 2008

Hypoxia increases synthesis of metalloproteinases in isolated rat lung mast cells

  • H Maxová, J Novotná, L Vajner, M Vízek, R Vytášek, J Herget
  • Phys Res
  • 2002

Similar Papers

Loading similar papers…