Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

@article{Sekido1993PreventionOL,
  title={Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8},
  author={Nobuaki Sekido and Naofumi Mukaida and Akihisa Harada and Isao Nakanishi and Yoh Watanabe and Kouji Matsushima},
  journal={Nature},
  year={1993},
  volume={365},
  pages={654-657}
}
RE-ESTABLISHING blood flow to ischaemic tissues causes greater injury than that induced during the ischaemic period1,2. This type of tissue injury, reperfusion injury, is involved in frostbite, multiple organ failure after hypovolaemia and in myocardial infarction1. Depletion of neutrophils alleviates reperfusion injury, implying a causal role of neutrophil infiltration3,4. Among members of the recently discovered family of chemotactic cytokines (chemo-kines)5–8, interleukin-8 (IL-8)5,9–13 is a… CONTINUE READING

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