Prevention of liver cirrhosis in rats by curcumin.

@article{Bruck2007PreventionOL,
  title={Prevention of liver cirrhosis in rats by curcumin.},
  author={Rafael Bruck and Michal Ashkenazi and Sigal Weiss and Ilana Goldiner and Haim Shapiro and Hussein Aeed and Olga Genina and Zamir Helpern and Mark Pines},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2007},
  volume={27 3},
  pages={373-83}
}
BACKGROUND AND AIM Curcumin, the major polyphenolic compound in turmeric, has been shown to attenuate hepatic damage in several animal models of liver injury. The aim of the present study was to examine the efficacy of curcumin in preventing thioacetamide-induced cirrhosis and to unravel the mechanism of curcumin's effect on hepatic fibrosis in rats. METHODS Liver cirrhosis was induced by thioacetamide (TAA; 200 mg/kg, i.p.) twice weekly for 12 weeks. One group of rats concomitantly received… CONTINUE READING
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