Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchange.

@article{GarciaDorado1997PreventionOI,
  title={Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchange.},
  author={David Garcia-Dorado and Miguel Angel Ponce Gonz{\'a}lez and Jos{\'e} Antonio Barrab{\'e}s and Marisol Ru{\'i}z-Meana and J. Ricardo Solares and Rosa Mar{\'i}a Lid{\'o}n and Jos{\'e} Blanco and Yolanda Puigfel and Hans Michael Piper and Jordi Soler-Soler},
  journal={Cardiovascular research},
  year={1997},
  volume={35 1},
  pages={80-9}
}
OBJECTIVE To determine the effect of Na(+)-H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. METHODS Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemic rigor (reduction in passive segment length change) and hypercontracture (reduction in end-diastolic length). RESULTS Pretreatment with the new, highly selective Na(+)-H… CONTINUE READING