Prevention of insect-borne disease: an approach using transgenic symbiotic bacteria.

@article{Durvasula1997PreventionOI,
  title={Prevention of insect-borne disease: an approach using transgenic symbiotic bacteria.},
  author={Ravi V. Durvasula and Andrew A. Gumbs and Anil A. Panackal and O Kruglov and Serap Aksoy and R. B. Merrifield and Frank F. Richards and Charles Ben Beard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 7},
  pages={3274-8}
}
Expression of molecules with antiparasitic activity by genetically transformed symbiotic bacteria of disease-transmitting insects may serve as a powerful approach to control certain arthropod-borne diseases. The endosymbiont of the Chagas disease vector, Rhodnius prolixus, has been transformed to express cecropin A, a peptide lethal to the parasite, Trypanosoma cruzi. In insects carrying the transformed bacteria, cecropin A expression results in elimination or reduction in number of T. cruzi. A… CONTINUE READING
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