Prevention of influenza by targeting host receptors using engineered proteins.

@article{Connaris2014PreventionOI,
  title={Prevention of influenza by targeting host receptors using engineered proteins.},
  author={Helen C. Connaris and Elena A Govorkova and Yvonne Ligertwood and Bernadette M. Dutia and Lei Yang and Sandra Tauber and Margaret Taylor and Nadiawati Alias and Robert Hagan and Anthony Nash and Robert James Webster and Garry L. Taylor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 17},
  pages={6401-6}
}
There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface… CONTINUE READING