Prevention of induced prostate-related cancer by soy protein isolate/isoflavone-supplemented diet in Lobund-Wistar rats.

@article{Pollard2000PreventionOI,
  title={Prevention of induced prostate-related cancer by soy protein isolate/isoflavone-supplemented diet in Lobund-Wistar rats.},
  author={Morris Pollard and William R. Wolter and Lin Sun},
  journal={In vivo},
  year={2000},
  volume={14 3},
  pages={389-92}
}
Based on epidemiological surveys, the low incidence of clinical prostate cancer among aged men in Japan and China were attributed to high consumption of soybean-derived food in which phytoestrogens have numerous anticancer mechanisms. The prostate model in Lobund-Wistar (L-W) rats produce high levels of testosterone (T). They are inherently predisposed to develop induced and spontaneous metastasizing adenocarcinomas, which are (T)-dependent in early stages and T-independent in advanced stages… CONTINUE READING