Prevention of hypertension attenuates albuminuria and renal expression of fibronectin in diabetic spontaneously hypertensive rats.

@article{Pavan2003PreventionOH,
  title={Prevention of hypertension attenuates albuminuria and renal expression of fibronectin in diabetic spontaneously hypertensive rats.},
  author={Malleshappa Pavan and Bruno Ghini and Mario Castro and Jos{\'e} Butori Lopes de Faria},
  journal={American journal of nephrology},
  year={2003},
  volume={23 6},
  pages={422-8}
}
BACKGROUND/AIM The aim of this study was to evaluate the effect of preventing hypertension on renal disease in a model of genetic hypertension and diabetes. METHODS Four-week-old spontaneously hypertensive rats (SHR) with streptozotocin-induced diabetes were randomized for no treatment, or for treatment with captopril, losartan or triple therapy (hydrochlorothiazide, reserpine and hydralazine) for 16 weeks. RESULTS Increase in systolic blood pressure was equally prevented by captopril (128… CONTINUE READING