Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4

Abstract

Apoptosis is an early event involved in cardiomyopathy associated with diabetes mellitus. Toll-like receptor (TLR) signaling triggers cell apoptosis through multiple mechanisms. Up-regulation of TLR4 expression has been shown in diabetic mice. This study aimed to delineate the role of TLR4 in myocardial apoptosis, and to block this process through gene… (More)
DOI: 10.1186/1479-5876-8-133

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