Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate.

@article{Ruml1995PreventionOH,
  title={Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate.},
  author={L A Ruml and Susan K Dubois and Michael L Roberts and Charles Pak},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1995},
  volume={10 4},
  pages={655-62}
}
The bone loss and hypercalciuria induced by immobilization or the decreased gravitational forces of space are well described. Using a model of bedrest immobilization, the ability of a potent aminobisphosphonate, alendronate, to avert hypercalciuria and stone-forming propensity was tested. Sixteen male subjects participated in a randomized, placebo-controlled trial in which they received either 20 mg of alendronate or placebo 2 weeks prior to and during 3 weeks of strict bedrest. Parameters of… CONTINUE READING