Prevention of hydroxyl radical formation: a critical concept for improving cardioplegia. Protective effects of deferoxamine.

@article{Menasch1987PreventionOH,
  title={Prevention of hydroxyl radical formation: a critical concept for improving cardioplegia. Protective effects of deferoxamine.},
  author={Philippe Menasch{\'e} and C Grousset and Y Gauduel and Christian Mouas and A H Piwnica},
  journal={Circulation},
  year={1987},
  volume={76 5 Pt 2},
  pages={V180-5}
}
The hydroxyl radical is one of the most damaging oxygen metabolites that are thought to be produced during ischemia and reperfusion of cardiac tissue. Therefore, we used the isolated, isovolumetric, buffer-perfused rat heart preparation of cardioplegic arrest to assess the effects of interventions targeted at inhibiting production of the hydroxyl radical by decreasing either the availability of one of its precursors (hydrogen peroxide) or that of the metal catalyst (ferric iron) involved in the… CONTINUE READING
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