Prevention of hereditary large bowel cancer: tissue culture assays and logistics.

  • Levy Kopelovich
  • Published 1983 in Progress in clinical and biological research


It is currently believed that normal genes, presumably in the class of tissue differentiation genes (proto-oncogenes), are responsible for the malignant transformation of human cells. As such, they cannot be appropriately used to identify individuals at risk for cancer. Based on our experience with a cell system from patients with adenomatosis of the colon and rectum (ACR), we suggest that predisposition to cancer can best be detected as a global syndrome at the phenotypic level. The ability to distinguish a cancer predisposed person from a normal individual in well-defined populations should qualify a test as "cancer specific". An underlying assumption in these studies is that predisposition to cancer, in general, is associated with an autosomal dominant trait in obligatory heterozygote gene carriers.

Cite this paper

@article{Kopelovich1983PreventionOH, title={Prevention of hereditary large bowel cancer: tissue culture assays and logistics.}, author={Levy Kopelovich}, journal={Progress in clinical and biological research}, year={1983}, volume={115}, pages={131-45} }