Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.

@article{Rosenfeld2000PreventionOH,
  title={Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.},
  author={Michael E Rosenfeld and L E Prichard and Nobuyoshi Shiojiri and Nelson Fausto},
  journal={The American journal of pathology},
  year={2000},
  volume={156 3},
  pages={997-1007}
}
Mice deficient in the nuclear factor kappaB (NF-kappaB)-transactivating gene RelA (p65) die at embryonic days 14-15 with massive liver apoptosis. In the adult liver, activation of the NF-kappaB heterodimer RelA/p50 can cause hepatocyte proliferation, apoptosis, or the induction of acute-phase response genes. We examined, during wild-type fetal liver development, the expression of the Rel family member proteins, as well as other proteins known to be important for NF-kappaB activation. We found… CONTINUE READING