Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension

@inproceedings{Kostis1997PreventionOH,
  title={Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension},
  author={John B. Kostis and Barry R. Davis and Jeffrey A. Cutler and Richard H. Grimm and Kenneth G. Berge and Jerome D. Cohen and Clifton R. Lacy and Helen Perry and M. Donald Blaufox and Sylvia Wassertheil-Smoller and R BlackHenry and Eleanor B Schron and David M. Berkson and J. David Curb and William M. Smith and Robert H. McDonald and William B. Applegate},
  year={1997}
}
Context. —Heart failure is often preceded by isolated systolic hypertension, but the effectiveness of antihypertensive treatment in preventing heart failure is not known. Objective. —To assess the effect of diuretic-based antihypertensive stepped-care treatment on the occurrence of heart failure in older persons with isolated systolic hypertension. Design. —Analysis of data from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Participants. —A total of 4736 persons… CONTINUE READING

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