Prevention of graft-versus-host disease using antibody to Thy 1. A role for complement in vivo.

Abstract

An in vitro assay was used to determine whether mouse complement (C') was able to lyse T cells coated with a monoclonal IgM anti-Thy-1 antibody. Using lymph node cells (LNC) as targets, it was found that antibody-coated mature T cells were efficiently lysed by serum from C57BL/6, but inefficiently lysed by serum from BALB/c mice. Serum from both strains… (More)

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