Prevention of graft-versus-host disease following allogeneic bone marrow transplantation in rats using FK506.

@article{Markus1991PreventionOG,
  title={Prevention of graft-versus-host disease following allogeneic bone marrow transplantation in rats using FK506.},
  author={Peter M. Markus and X Cai and W Ming and A J Demetris and J J Fung and T E Starzl},
  journal={Transplantation},
  year={1991},
  volume={52 4},
  pages={590-4}
}
  • Peter M. Markus, X Cai, +3 authors T E Starzl
  • Published 1991 in Transplantation
FK506 and cyclosporine were used for the prevention of acute graft-versus-host disease. Acute GVHD was induced in Lewis rats by total-body irradiation and subsequent reconstitution with allogeneic (ACI) bone marrow and spleen cells (BMTx). GVHD was assessed by both clinical and histologic parameters during the experiment duration of 60 days, and longer for selected animals. All untreated BM recipients died within 26 days from severe acute GVHD. GVHD was prevented with CsA during the period of… CONTINUE READING