Prevention of glutathione depletion-induced apoptosis in cultured human RPE cells by flupirtine.

@article{Wood1998PreventionOG,
  title={Prevention of glutathione depletion-induced apoptosis in cultured human RPE cells by flupirtine.},
  author={John P. M. Wood and Gabriela Pergande and Neville N Osborne},
  journal={Restorative neurology and neuroscience},
  year={1998},
  volume={12 2-3},
  pages={119-25}
}
We have recently reported that the non-opiate analgesic, flupirtine, counteracts apoptosis in cultures of human retinal pigmented epithelial (RPE) cells induced by deprivation of serum, oxygen and glucose (experimental ischaemia). In the present study, human RPE cells grown on coverslips were treated with buthionine sulphoxamine (BSO), a compound that inhibits glutathione biosynthesis. BSO caused a dose-dependent reduction in culture density and an increase in the number of cell nuclei that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…