Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.

@article{Ehsanullah1988PreventionOG,
  title={Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.},
  author={Raihana S. B. Ehsanullah and M. C. Page and G Tildesley and John R. Wood},
  journal={BMJ},
  year={1988},
  volume={297 6655},
  pages={1017-21}
}
OBJECTIVE To evaluate the prophylactic effect of ranitidine 150 mg twice daily in patients requiring one of the following non-steroidal anti-inflammatory drugs: naproxen, piroxicam, diclofenac, and indomethacin. In addition, risk factors were studied in order to help in targeting of such treatment to specific groups of patients. DESIGN Double blind, placebo controlled, randomised, parallel group with endoscopic assessments at 0, 4, and 8 weeks. SETTING Multicentre outpatient study at… CONTINUE READING

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