Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12.

@article{Yokoi1997PreventionOE,
  title={Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12.},
  author={Haruhiko Yokoi and Kazunori Kato and Takeshi Kezuka and J Sakai and Masahiko Usui and H. Yagita and Ko Okumura},
  journal={European journal of immunology},
  year={1997},
  volume={27 3},
  pages={641-6}
}
Experimental autoimmune uveoretinitis (EAU) induced by immunization with interphotoreceptor retinoid-binding protein (IRBP), a retinal self antigen, has been regarded to be a typical T helper type 1 (Th1)-mediated inflammatory disease. In this study, we examined the effect of a neutralizing monoclonal antibody (mAb) to interleukin-12 (IL-12), which has been known to play a critical role in the Th1 differentiation, on the development of EAU. While 9 of 13 control mice developed EAU by the… CONTINUE READING
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