Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

@article{Yednock1992PreventionOE,
  title={Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.},
  author={Ted A. Yednock and Catherine Cannon and Sean Konrad Mchugh and Francisco S{\'a}nchez-Madrid and Lawrence Steinman and Nathan Karin},
  journal={Nature},
  year={1992},
  volume={356 6364},
  pages={
          63-6
        }
}
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory condition of the central nervous system with similarities to multiple sclerosis. In both diseases, circulating leukocytes penetrate the blood-brain barrier and damage myelin, resulting in impaired nerve conduction and paralysis. We sought to identify the adhesion receptors that mediate the attachment of circulating leukocytes to inflamed brain endothelium in EAE, because this interaction is the first step in leukocyte entry into… CONTINUE READING

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