Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction.

@article{Hassoun2008PreventionOE,
  title={Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction.},
  author={Sidi Mohammed Hassoun and Xavier Mar{\'e}chal and David Montaigne and Youcef Bouazza and Brigitte Decoster and Steve Lancel and Remi R Neviere},
  journal={Critical care medicine},
  year={2008},
  volume={36 9},
  pages={2590-6}
}
OBJECTIVE Growing evidence suggests that mitochondria function is impaired in sepsis. Here, we tested the hypothesis that lipopolysaccharide would induce mitochondrial Ca2+ overload and oxygen utilization abnormalities as consequences of sarcoplasmic reticulum Ca2+ handling derangements that are typically observed in sepsis. As lipopolysaccharide-induced sarcoplasmic reticulum dysfunction was mainly characterized by reduced sarcoplasmic reticulum Ca2+ uptake and Ca2+ leak, we tested whether… CONTINUE READING
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