Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I.

@article{Flegel1993PreventionOE,
  title={Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I.},
  author={Willy Albert Flegel and Manfred W. Baumstark and Christof Weinstock and Alex G. Berg and Hinnak Northoff},
  journal={Infection and immunity},
  year={1993},
  volume={61 12},
  pages={5140-6}
}
Interaction of endotoxin (lipopolysaccharide [LPS]) with human lipoproteins is known to prevent the LPS-induced activation of human monocytes and release of cytokines (monokines). LPS was exposed to lipoprotein classes separated by ultracentrifugation and to apolipoprotein A-I. Then monocytes were added, and the LPS activation of monocytes was determined by measuring the induced monokines. Failure of LPS to induce monokine release was called LPS inactivation caused by lipoproteins or… CONTINUE READING

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