Prevention of endothelial dysfunction in heart failure by vitamin E: attenuation of vascular superoxide anion formation and increase in soluble guanylyl cyclase expression.

@article{Bauersachs2001PreventionOE,
  title={Prevention of endothelial dysfunction in heart failure by vitamin E: attenuation of vascular superoxide anion formation and increase in soluble guanylyl cyclase expression.},
  author={Johann Bauersachs and Ingrid Fleming and Daniela Fraccarollo and R. S. Busse and Georg Ertl},
  journal={Cardiovascular research},
  year={2001},
  volume={51 2},
  pages={344-50}
}
OBJECTIVES Enhanced vascular superoxide anion generation contributes to endothelial dysfunction in heart failure. However, the effect of long-term treatment with the antioxidant vitamin E is unknown. METHODS AND RESULTS Relaxant responses were determined in aortic rings from Wistar rats with heart failure 12 weeks after myocardial infarction (MI) and compared with responses in tissues from sham-operated animals. From the seventh post-operative day, rats were given either a standard chow or a… CONTINUE READING