Prevention of endometrial cancer with progestogens.

  title={Prevention of endometrial cancer with progestogens.},
  author={R. D. Gambrell},
  volume={8 2},
Unopposed oestrogen replacement therapy increases the risk of endometrial cancer in post-menopausal women. However, the addition of progestogen to the oestrogen therapy reduces the risk of endometrial carcinoma by preventing and effectively treating hyperplasia of the endometrium. In a 5-yr prospective study with a further 4 yr of follow-up (1975-83), 31 adenocarcinomas of the endometrium were detected over 27243 patient-years of observation, for an incidence of 113.8:100 000 women. The first… CONTINUE READING


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