Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer.

@article{Lin2009PreventionOE,
  title={Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer.},
  author={Yi Lin and Huiqi Wang and Wenjing Wang and Shan Zeng and Yanmin Zhong and D D Li},
  journal={Reproduction},
  year={2009},
  volume={137 6},
  pages={943-55}
}
Both regulatory T cells and regulatory natural killer (NK) cells may play essential roles in the maintenance of pregnancy. In this study, we show that a significantly high percentage of spontaneous embryo loss was observed in both allogeneic and syngeneic pregnant non-obese diabetic (NOD) mice. The percentage of embryo loss in allogeneic pregnant mice was further increased by the administration of anti-asialo ganglio-N-tetraosylceramide to deplete NK cells, but was decreased by the adoptive… CONTINUE READING

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