Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid

@article{Knyihrcsillik2007PreventionOE,
  title={Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid},
  author={Elizabeth Knyih{\'a}r-csillik and J{\'o}zsef Toldi and Be{\'a}ta Krisztin-P{\'e}va and Zolt{\'a}n Chadaide and L{\'a}szl{\'o} V{\'e}csei},
  journal={Neuroscience Letters},
  year={2007},
  volume={418},
  pages={122-126}
}
The systemic administration of nitroglycerine, regarded as a migraine model, was previously observed to result in an increased number of c-fos immunoreactive secondary sensory neurons in the caudal trigeminal nucleus, which forward nociceptive impulses to the thalamus. The present investigation tested the hypothesis of whether kynurenine in combination with systemically administered probenecid protects second-order trigeminal neurons against stimulation arriving via central processes of… CONTINUE READING

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