Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females.

@article{Christiansen1980PreventionOE,
  title={Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females.},
  author={Claus Christiansen and Merete Sanvig Christensen and Peter McNair and Claus Hagen and K E Stocklund and Ib. Transb\ol},
  journal={European journal of clinical investigation},
  year={1980},
  volume={10 4},
  pages={273-9}
}
With the aim of preventing postmenopausal bone loss, a placebo-controlled double-blind trial of 2 years duration was performed. We randomized 315 healthy volunteers in their early natural menopause to seven treatment and three placebo groups: 17 beta-oestradiol, oestriol and sequential norethisteron (hormones); bendroflumethiazide 5 mg/day (thiazide); hormones and thiazide; sodium fluoride 20 mg/day; vitamin D3 2000 IU/day (D3); fluoride and D3; and 1 alpha (OH) vitamin D3 0.25 microgram/day (1… CONTINUE READING

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