Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.

@article{Tilton1993PreventionOD,
  title={Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.},
  author={Ronald G. Tilton and Kathy C. Chang and Khader Hasan and Steven R. Smith and J. Mark Petrash and Thomas P. Misko and William M. Moore and Mark G. Currie and John A Corbett and Michael L. McDaniel},
  journal={Diabetes},
  year={1993},
  volume={42 2},
  pages={221-32}
}
This study was undertaken to compare the ability of two guanidine compounds (aminoguanidine and methylguanidine), with different in vitro effects on NO synthase activity and AGE formation, to inhibit diabetic vascular dysfunction developing early after the onset of diabetes. In rats with STZ-induced diabetes of 5-wk duration, regional vascular [125I]albumin permeation was increased about two- to threefold in ocular tissues, sciatic nerve, and aorta; in general, both guanidine compounds… CONTINUE READING
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